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Detoxing Cisplatin
#45569
11/26/08 12:41 PM
11/26/08 12:41 PM
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OP
Master Elite Member
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Joined: Dec 1999
Posts: 30,797
Maine, USA
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CisplatinCisplatin is a platinum-based toxin that contains platinum, chlorine, and ammonia. It's important to perform a long-term platinum detox to get rid of any remaining elemental platinum that may remain. The harmful effects of Cisplatin include renal insufficiency (weak kidneys) and tubular dysfunction (inability for kidneys to remove acids from the blood). In large doses it causes: - oliguric renal failure (kidney failure), - hepatotoxicity (liver damage), - ototoxicity (damage to the ear), - peripheral neuropathy (damage to the nervous system in the outer limbs--hands, feet, eyes, ears, etc.), - blindness, - and severe myelosuppression (decrease in red AND white blood cell production). The supplements that we would take are: - Milk Thistle Combination (1 capsule per day to start, increasing doses every two weeks or as tolerable) http://onlythebestherbs.com/index.php?do=DisplayProduct_NSP&StockNum=4076-5- Vitamin E with Selenium (2 capsules per day) http://onlythebestherbs.com/index.php?do=DisplayProduct_NSP&StockNum=1509-8The standard supplement for detoxing platinum is N-Acetyl-Cysteine (NAC) which is contained in Milk Thistle Combination and is a glutathione precursor. Platinum depletes selenium so a selenium supplement is also recommended. Selenium should normally be accompanied with Vitamin E, which is why better manufacturers include both in a single supplement. I would start the NAC at minimum doses because it mobilizes platinum which can make you have syptoms reccur in the beginning. Increase dose slowly with time. Resources The following articles make good reading: http://jasn.asnjournals.org/cgi/reprint/8/10/1640
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